![]() ![]() The peak integration data were analyzed by TopSpin software of the NMR spectrophotometer as well as by MestReNova software from Mestrelab Research. The peak area of three sets of protons in acetaminophen – methyl group peak and two sets of aromatic ring peaks – were quantified with respect to the methyl group peak area of the internal standard, ethanol. ![]() ![]() Two sets of concentrations of acetaminophen in deuterated dimethyl sulfoxide – ranging from 10 mM to 100 mM and 1 mM to 10 mM – were analyzed using ethanol as an internal standard in septuplicate to show the robustness of the method. In this study, quantitative analysis of acetaminophen (active ingredient of Tylenol) was accomplished by q-NMR technique using a Bruker 300 MHz NMR instrument. Quantitative 1H-NMR technique (q-NMR) provides a rapid, selective, and accurate method for quantification of wide variety of organic compounds using minimal solvent, thus making it an environment friendly technique. ![]()
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